Chronic gastritis is a long-term, chronic inflammatory-dystrophic disorder of the gastric mucous membrane. The disease lasts for a long time and gradually the inflammatory process, which takes place in the mucous membrane of the GI tract leads to its degradation. The normal structure of the membrane is altered. The mucous membrane cells, gastric glands and sub-mucous membrane is being atrophied, and with time is replaced by connective tissue, with the loss of their function. Changes in secretion and motor activity of the stomach when the disease starts to progress are not expressed, and progress with time.
Chronic gastritis is a common disease as 50 to 85% of the adult population suffer from it. The frequency of the disease appearance increases proportionally with the age of the patients.
Currently the main reason for the gastritis appearance is considered to be infection with Helicobacter Pylori, a microorganism. At the current time 9 different species of the microorganism have been determined. The microorganism penetrates the protective barrier of the mucous membrane, attaches to the membrane, replicates, damages gastric cells , thus causing the development of chronic gastritis.
The role of Helicobacter pylori has been proven in 80% of chronic gastritis development.
Other factors are currently described as the ones promoting the development of chronic gastritis amongst them are: